List Categories | List All Articles | List Articles By Title
Creatine: More than a Sports Nutrition Supplement
Although creatine offers an array of benefits, most people think of it simply as a supplement that bodybuilders and other athletes use to gain strength and muscle mass. Nothing could be further from the truth.
A substantial body of research has found that creatine may have a wide variety of uses. In fact, creatine is being studied as a supplement that may help with diseases affecting the neuromuscular system, such as muscular dystrophy (MD).
Recent studies suggest creatine may have therapeutic applications in aging populations for wasting syndromes, muscle atrophy, fatigue, gyrate atrophy, Parkinson's disease, Huntington's disease and other brain pathologies. Several studies have shown creatine can reduce cholesterol by up to 15% and it has been used to correct certain inborn errors of metabolism, such as in people born without the enzyme(s) responsible for making creatine.
Some studies have found that creatine may increase growth hormone production.
What is creatine?
Creatine is formed in the human body from the amino acids methionine, glycine and arginine. The average person's body contains approximately 120 grams of creatine stored as creatine phosphate. Certain foods such as beef, herring and salmon, are fairly high in creatine.
However, a person would have to eat pounds of these foods daily to equal what can be obtained in one teaspoon of powdered creatine.
Creatine is directly related to adenosine triphosphate (ATP). ATP is formed in the powerhouses of the cell, the mitochondria. ATP is often referred to as the "universal energy molecule" used by every cell in our bodies. An increase in oxidative stress coupled with a cell's inability to produce essential energy molecules such as ATP, is a hallmark of the aging cell and is found in many disease states.
Key factors in maintaining health are the ability to: (a) prevent mitochondrial damage to DNA caused by reactive oxygen species (ROS) and (b) prevent the decline in ATP synthesis, which reduces whole body ATP levels. It would appear that maintaining antioxidant status (in particular intra-cellular glutathione) and ATP levels are essential in fighting the aging process.
It is interesting to note that many of the most promising anti-aging nutrients such as CoQ10, NAD, acetyl-l-carnitine and lipoic acid are all taken to maintain the ability of the mitochondria to produce high energy compounds such as ATP and reduce oxidative stress.
The ability of a cell to do work is directly related to its ATP status and the health of the mitochondria. Heart tissue, neurons in the brain and other highly active tissues are very sensitive to this system. Even small changes in ATP can have profound effects on the tissues' ability to function properly.
Of all the nutritional supplements available to us currently, creatine appears to be the most effective for maintaining or raising ATP levels.
How does creatine work?
In a nutshell, creatine works to help generate energy. When ATP loses a phosphate molecule and becomes adenosine diphosphate (ADP), it must be converted back to ATP to produce energy. Creatine is stored in the human body as creatine phosphate (CP) also called phosphocreatine.
When ATP is depleted, it can be recharged by CP. That is, CP donates a phosphate molecule to the ADP, making it ATP again. An increased pool of CP means faster and greater recharging of ATP, which means more work can be performed.
This is why creatine has been so successful for athletes. For short-duration explosive sports, such as sprinting, weight lifting and other anaerobic endeavors, ATP is the energy system used.
To date, research has shown that ingesting creatine can increase the total body pool of CP which leads to greater generation of energy for anaerobic forms of exercise, such as weight training and sprinting. Other effects of creatine may be increases in protein synthesis and increased cell hydration.
Creatine has had spotty results in affecting performance in endurance sports such as swimming, rowing and long distance running, with some studies showing no positive effects on performance in endurance athletes.
Whether or not the failure of creatine to improve performance in endurance athletes was due to the nature of the sport or the design of the studies is still being debated.
Creatine can be found in the form of creatine monohydrate, creatine citrate, creatine phosphate, creatine-magnesium chelate and even liquid versions.
However, the vast majority of research to date showing creatine to have positive effects on pathologies, muscle mass and performance used the monohydrate form. Creatine monohydrate is over 90% absorbable. What follows is a review of some of the more interesting and promising research studies with creatine.
Creatine and neuromuscular diseases
One of the most promising areas of research with creatine is its effect on neuromuscular diseases such as MD. One study looked at the safety and efficacy of creatine monohydrate in various types of muscular dystrophies using a double blind, crossover trial.
Thirty-six patients (12 patients with facioscapulohumeral dystrophy, 10 patients with Becker dystrophy, eight patients with Duchenne dystrophy and six patients with sarcoglycan-deficient limb girdle muscular dystrophy) were randomized to receive creatine or placebo for eight weeks.
The researchers found there was a "mild but significant improvement" in muscle strength in all groups. The study also found a general improvement in the patients' daily-life activities as demonstrated by improved scores in the Medical Research Council scales and the Neuromuscular Symptom scale. Creatine was well tolerated throughout the study period, according to the researchers.1
Another group of researchers fed creatine monohydrate to people with neuromuscular disease at 10 grams per day for five days, then reduced the dose to 5 grams per day for five days.
The first study used 81 people and was followed by a single-blinded study of 21 people.
In both studies, body weight, handgrip, dorsiflexion and knee extensor strength were measured before and after treatment. The researchers found "Creatine administration increased all measured indices in both studies." Short-term creatine monohydrate increased high-intensity strength significantly in patients with neuromuscular disease.2
There have also been many clinical observations by physicians that creatine improves the strength, functionality and symptomology of people with various diseases of the neuromuscular system.
Creatine and neurological protection/brain injury
If there is one place creatine really shines, it's in protecting the brain from various forms of neurological injury and stress. A growing number of studies have found that creatine can protect the brain from neurotoxic agents, certain forms of injury and other insults.
Several in vitro studies found that neurons exposed to either glutamate or beta-amyloid (both highly toxic to neurons and involved in various neurological diseases) were protected when exposed to creatine.3 The researchers hypothesized that "? cells supplemented with the precursor creatine make more phosphocreatine (PCr) and create larger energy reserves with consequent neuroprotection against stressors."
More recent studies, in vitro and in vivo in animals, have found creatine to be highly neuroprotective against other neurotoxic agents such as N-methyl-D-aspartate (NMDA) and malonate.4 Another study found that feeding rats creatine helped protect them against tetrahydropyridine (MPTP), which produces parkinsonism in animals through impaired energy production.
The results were impressive enough for these researchers to conclude, "These results further implicate metabolic dysfunction in MPTP neurotoxicity and suggest a novel therapeutic approach, which may have applicability in Parkinson's disease."5 Other studies have found creatine protected neurons from ischemic (low oxygen) damage as is often seen after strokes or injuries.6
Yet more studies have found creatine may play a therapeutic and or protective role in Huntington's disease7, 8 as well as ALS (amyotrophic lateral sclerosis).9 This study found that "? oral administration of creatine produced a dose-dependent improvement in motor performance and extended survival in G93A transgenic mice, and it protected mice from loss of both motor neurons and substantia nigra neurons at 120 days of age.
Creatine administration protected G93A transgenic mice from increases in biochemical indices of oxidative damage. Therefore, creatine administration may be a new therapeutic strategy for ALS." Amazingly, this is only the tip of the iceberg showing creatine may have therapeutic uses for a wide range of neurological disease as well as injuries to the brain.
One researcher who has looked at the effects of creatine commented, "This food supplement may provide clues to the mechanisms responsible for neuronal loss after traumatic brain injury and may find use as a neuroprotective agent against acute and delayed neurodegenerative processes."
Creatine and heart function
Because it is known that heart cells are dependent on adequate levels of ATP to function properly, and that cardiac creatine levels are depressed in chronic heart failure, researchers have looked at supplemental creatine to improve heart function and overall symptomology in certain forms of heart disease.
It is well known that people suffering from chronic heart failure have limited endurance, strength and tire easily, which greatly limits their ability to function in everyday life. Using a double blind, placebo-controlled design, 17 patients aged 43 to 70 years with an ejection fraction
The Real Truth About Supplements
Not All Supplements are Created Equal. There are more supplements available than I would care to count and keep track of.
Can You Drink Your Way To Good Health?
Many years ago I became convinced of the need to take vitamin and mineral supplements. Although I tried to eat healthy meals, mixing salads, fruits and vegetables, proteins and grains as wisely as I could, numerous studies pointed out the need to add nutritional supplements to my diet.
Amended Bitter Orange - Ephedra in Disguise? So Why Do People Still Take It ?
If you read my last article about bitter orange, it was pretty clear how I felt about the herb. I'd read the available research concerning bitter orange, and while there was some evidence supporting bitter orange, the overall picture did not look good.
Health Benefits of Taking Spirulina Daily - Real Health Part 5
As I mentioned in Part 4 of my Real Health diet series, I believe that taking green foods, particularly spirulina and chlorella, is very important to your health. This article will focus on why you should take spirulina.
The Frightening But True Facts About Smoking
If you think that smoking is a harmless little hobby and all the people harping on you to quit are overreactors, think again. Smoking is the number ONE preventable cause of premature death and morbidity in America.
Eat Well First Before You Take Your Vitamins
There is a huge market when it comes to vitamins. Every Walmart and Walgreens across the nation are stocked with shelves and shelves of vitamins and minerals.
Congestive Heart Failure And CoQ10
Since the 1960â??s there have been numerous controlled clinical trials concerning the relationship between congestive heart failure and Coenzyme Q10 (CoQ10). As its name implies CoQ10 is a coenzyme that is necessary for the proper functioning of other substances, one of the most important of which is ATP (adenosine triphosphate).
Creatine, Caffeine, and Carbohydrates - Supplements That Work
It would seem that everyone is looking to squeeze the most out of their training investment and as a result, the supplement industry has globally become a multi-billion dollar industry. There are however very few legal ergogenic (performance enhancing) supplements on the market whose benefits are proven and whose negative side effects are minimal.
GABA: An Inexpensive, Natural, and Effective Way to Increase HGH
Suppose you can turn back the hands of time to 10 years ago. You would look younger, have more energy, and be slimmer.
Protein Supplement - whey protein.Why is protein supplement important? Protein has many benefits and if you body doesn't get enough protein from other sources like food, protein supplement is a great substitute.
Omega 3 and Reduced Risk of Myocardial Infarction
Myocardial infarction is a technical term used to describe an irreversible injury to heart muscle. It is normally used as a synonym for a heart attack and will be so used in this essay.
Vitamin A - The Glow-in-the-dark Vitamin
The ancient Egyptians had a cure for "night blindness". They fed the patient lots and lots of liver.
Beta-Glucan May Prevent Anthrax When Taken Orally
In a 2002 study, a group of researchers used oral Beta Glucan to treat mice infected with Bacillus Anthracites. With the high incidence of anthrax vaccine complications, an alternative preventative approach is sorely needed to deal with this frightening disease.
Vitamin Information for Health
Vitamin C may be the most famous vitamin. Tens of thousands of British sailors were dying of the disease scurvy until they began taking limes and other citrus fruit along on voyages.
Vitamin C May Improve Smokers Blood Circulation
A dose of vitamin C may give a quick boost to the poorer-than-average blood circulation seen in healthy young smokers, a study suggests. The study of 25 healthy men found that although smokers initially showed poorer results on a test of blood flow to the heart that changed after they took a large dose - 2 grams - of vitamin C.
What Can Muscle Milk Do For Me?
As the name suggests, muscle milk is a supplement that is rich in the proteins necessary for ultimate muscle growth and fitness. Essentially having its beginnings in the composition of human mother's milk after much research muscle milk emerges as a much-improved version.
Beyond Macronutrients and the Importance of Vitamin Supplements
Most healthy eaters are familiar with the three macronutrients that garner the most media attention within the diet world: proteins, carbohydrates, and fats. Indeed, some highly regarded eating programs, such as the Isometric Diet®, are designed to deliver an optimal balance of these three macronutrients.
Immune System Supplement
Your Immune system Needs BalanceTaking an immune system supplement daily is very important. However most of us don't do it until we get sick or don't feel good.
What is a Supplement?
Supplement - what is it?Supplement is a term that means products made of one or more of the fundamental nutrients, for example vitamins, minerals, and proteins. It provides you with some specific (or a mix of) vitamins, minerals, herbs, botanicals, amino acids, metabolites, etc.
Taste is Everything When Choosing a Protein Bar
As consumers, we are faced daily with choices about what to eat. As a bodybuilder, we are bombarded with protein bars that promise everything from tons of protein, low carbs, less fat, and the cheapest bar on the market.
home | site map
All articles are copyright to their owners.
Note: this website lists articles, We do not Write Articles !